发明名称 |
Use of substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1H)one derivatives as therapeutic agents |
摘要 |
The invention relates to an use of pyrimidone derivative represented by formula (I) or a salt thereof: wherein m, n, p, X, Y, R1, R2, R3, R4 and R5 are as defined herein for treating a variety of disease states. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3beta or GSK3beta and cdk5/p25, such as Alzheimer's disease.
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申请公布号 |
US7462621(B2) |
申请公布日期 |
2008.12.09 |
申请号 |
US20070696982 |
申请日期 |
2007.04.05 |
申请人 |
SANOFI-AVENTIS;MITSUBISHI PHARMA CORPORATION |
发明人 |
GALLET THIERRY;LARDENOIS PATRICK;LOCHEAD ALISTAIR;MARGUERIE SEVERINE;NEDELEC ALAIN;SAADY MOURAD;SLOWINSKI FRANCK;YAICHE PHILIPPE |
分类号 |
C07D487/04;A61K31/519;A61K31/55;A61P3/04;A61P3/10;A61P9/10;A61P17/14;A61P25/00;A61P25/02;A61P25/08;A61P25/16;A61P25/18;A61P25/24;A61P25/28;A61P27/02;A61P27/06;A61P35/00;A61P43/00;C07D213/50;C07D213/60 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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