发明名称 |
Methods for identifying agents which alter histone protein acetylation |
摘要 |
Methods of identifying agents which alter the NAD-dependent acetylation status and mono-ADP-ribosylation of nuclear proteins are disclosed. The methods further include identifying agents which alter the life span or aging of a cell or an organism by determining the level of NAD-dependent acetylation and/or ADP ribosylation of a nuclear protein. The invention also relates to a mammalian Sir2 protein which acetylates or deacetylates nuclear proteins in a NAD-dependent manner and has mono-ADP-ribosyltransferase activity. Host cells producing the Sir2 protein and antibodies to the Sir2 protein are also provided.
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申请公布号 |
US7452664(B2) |
申请公布日期 |
2008.11.18 |
申请号 |
US19990461580 |
申请日期 |
1999.12.15 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
GUARENTE LEONARD;IMAI SHIN-ICHIRO;ARMSTRONG CHRISTOPHER |
分类号 |
C12Q1/68;A61K38/17;C12Q1/48;G01N33/53;G01N33/66 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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