ALPHAVIRUS REPLICON PARTICLES ENCODING IL- 12 AS IMMUNOLOGICAL ADJUVANTS
摘要
The immune response to an antigen of interest, either in purified form or expressed via an alphavirus replicon particle, can be enhanced by the simultaneous administration of an alphavirus replicon particle which expresses interleukin-12. This allows for the use of significantly smaller quantities of the antigen and this immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.
申请公布号
WO2008085557(A3)
申请公布日期
2008.11.13
申请号
WO2007US78314
申请日期
2007.09.12
申请人
ALPHAVAX, INC.;SMITH, JONATHAN F.;HUBBY, BOLYN;BERGLUND, PETER;COPP, LAURA;ELLIS, WHITNEY
发明人
SMITH, JONATHAN F.;HUBBY, BOLYN;BERGLUND, PETER;COPP, LAURA;ELLIS, WHITNEY