发明名称 |
Process for the Preparation of Polymorphs, Solvates of Aripiprazole Using Aripiprazole Acid Salts |
摘要 |
The present invention relates to the novel compounds Methyl 2-[(3S)-[3-[(2E)(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-halopropyl]benzoates (IV) wherein the halo is chloro, bromo, iodo, starting from the known compound Methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-hydroxypropyl]benzoate (1). Reaction of Methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-hydroxypropyl]benzoate (1) with thionyl chloride or with methane sulfonyl chloride-lithium bromide or with trimethyl chlorosilane-sodium iodide in presence or absence of base gives Methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-halopropyl]benzoates.
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申请公布号 |
US2008275243(A1) |
申请公布日期 |
2008.11.06 |
申请号 |
US20070791048 |
申请日期 |
2007.05.17 |
申请人 |
SATYANARAYANA CHAVA;RAMANJANEYULU GORANTLA SEETA;SUNIL KUMAR INDUKURI VENKATA;SRINIVAS SIMHADRI |
发明人 |
SATYANARAYANA CHAVA;RAMANJANEYULU GORANTLA SEETA;SUNIL KUMAR INDUKURI VENKATA;SRINIVAS SIMHADRI |
分类号 |
C07D215/00 |
主分类号 |
C07D215/00 |
代理机构 |
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代理人 |
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地址 |
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