MUSCARINIC AGONISTS AND METHODS OF USE THEREOF

摘要

A method of forming analogs of CDD- 0304, i.e., tetra(ethyleneglycol) (4- methoxy-1,2,5-thiadiazol-3-yl)[3-(1-methyl-1,2,4,5-tetrahydropyrid-3-yl)-1,2,5- thiadiazo1-4-yl] ether hydrochloride includes replacing the 1,2,5-thiadiazole moiety with a terminal nitrogen moiety or an OH group; and b) varying the length of the linking group by replacing the tetra (ethylene) glycol moiety with one of: ethylene glycol, di(ethylene) glycol, penta(ethylene) glycol, or diether diol. Also, such analog compounds and their uses are disclosed.