METHOD AND DEVICE FOR MINIMALLY INVASIVE SITE SPECIFIC OCULAR DRUG DELIVERY

摘要

The present invention includes techniques for delivering an active agent into the eye of a subject. Accordingly, in one aspect a method may include delivering invasively an active agent into a peripheral tissue of the eye to form a drug reservoir, and applying an electric current to the drug reservoir to thus drive at least a portion of the active agent at least partially through the choroid. Numerous configurations are contemplated for the positioning of the electric current relative to the drug reservoir. For example, in one aspect the electric current may be applied to the drug reservoir from a non-invasively positioned electrode. In another aspect, the electric current may be applied to the drug reservoir from an invasively positioned electrode. A variety of invasive positions are contemplated, including, for example, positioning the invasive electrode within the peripheral tissue. In yet another aspect, delivering the active agent may further include implanting an invasive electrode having an associated drug reservoir containing the active agent into the peripheral tissue.