USE OF FIBRINOGEN AS A PROPHYLACTIC TREATMENT TO PREVENT BLEEDING DURING AND AFTER SURGERY AND AS A BIOMARKER TO IDENTIFY PATIENT WITH AN INCREASED RISK FOR EXCESSIVE BLEEDING AND BLOOD TRANSFUSION
摘要
<p>The present invention provides a method for preventing peri- and postoperative bleeding in subjects undergoing surgery, in particular subjects with a preoperative fibrinogen plasma level equal to or above the normal range. The method comprises administration of a substance with fibrinogen-like activity to the subject in an amount that result in a circulating fibrinogen plasma level of from about 1.0 g/L. The present invention also provides a method for determining the risk of subjects with a preoperative fibrinogen plasma level equal to or above the normal range to bleed postoperatively. Furthermore, the present invention provides means for predicting the necessity of blood or plasma transfusion after a subject with a preoperative fibrinogen plasma level equal to or above the normal range has been subject to a surgical procedure. The means involves measurement of the fibrinogen level of the subject before surgery and comparing the level with a risk curve.</p>
申请公布号
WO2008092656(A1)
申请公布日期
2008.08.07
申请号
WO2008EP00710
申请日期
2008.01.30
申请人
JEPPSSON, ANDERS;SKRTIC, STANKO;BRUCE, LENNART;JOHNSSON, JOERGEN;HEDNER, THOMAS
发明人
JEPPSSON, ANDERS;SKRTIC, STANKO;BRUCE, LENNART;JOHNSSON, JOERGEN;HEDNER, THOMAS