发明名称 |
IMAGING AGENTS FOR USE IN MAGNETIC RESONANCE BLOOD FLOW/PERFUSION IMAGING |
摘要 |
. In one aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a compound having at least one hyperpolarized nucleus having a T<SUB>1</SUB> greater than 15 seconds and a water-octanol partition coefficient between -1 and 1, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal. In another aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a carbon- 13 enriched alcohol, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal. |
申请公布号 |
WO2007149454(A3) |
申请公布日期 |
2008.06.19 |
申请号 |
WO2007US14310 |
申请日期 |
2007.06.19 |
申请人 |
BETH ISREAL DEACONESS MEDICAL CENTER, INC.;ALSOP, DAVID;VINOGRADOV, ELENA;GRANT, AARON;LENKINSKI, ROBERT |
发明人 |
ALSOP, DAVID;VINOGRADOV, ELENA;GRANT, AARON;LENKINSKI, ROBERT |
分类号 |
A61K49/10 |
主分类号 |
A61K49/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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