QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS.

摘要

Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R¹ is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R² is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula ; R³ is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R⁴ and R⁵ are hydrogen, alkyl or benzyl; or R⁴ and R⁵ together and including the N to which they are attached may form a ring; R⁶ is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl ; or two vicinal R⁶ radicals may be taken together to form a bivalent radical of formula - CH=CH-CH=CH-; r is 1, 2, 3, 4 or 5; R⁷ is hydrogen, alkyl, Ar or Het; R⁸ is hydrogen or alkyl; R⁹ is oxo ; or R⁸ and R⁹ together form the radical -CH=CH-N=.