Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
申请公布号
WO2007139982(A2)
申请公布日期
2007.12.06
申请号
WO2007US12588
申请日期
2007.05.23
申请人
SANGAMO BIOSCIENCES, INC.;ANDO, DALE;HOLMES, MICHAEL CHRISTOPHER;LEE, GARY KA LEONG
发明人
ANDO, DALE;HOLMES, MICHAEL CHRISTOPHER;LEE, GARY KA LEONG