| 摘要 |
Described are compounds of formula (I), wherein R1 is hydrogen or hydroxy; R 2, R2' and R2'', are each independently of the others hydrogen or a substituent other than hydrogen; either R3 is hydrogen or a substituent other than hydrogen and R4 is hydrogen or lower alkyl, or R3 and R4 together form a divalent radical of the formula -(CH2)n- wherein n is 2 or 3; R5 and R6 are each indenpendently of the other hydrogen, alkyl or aryl; and either R7 and R8 are each hydrogen, or R7 and R8 together form a bond; tautomers thereof, provided that at least one tautomerisable group is present; and salts thereof. The compoun ds inhibit the enzyme S-adenosylmethionine decarboxylase and are suitable, for example, for the treatment of tumors and protozoal infections.
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