| 摘要 |
A method of constructing a gene function database comprising measuring the cell viabilities, against a plural number of drugs at various concentrations, of transformed eukaryotic cells overexpressing a plural number of function-known genes and parental cell line thereof, calculating the ratios of IC40 values of the transformed cells to the IC40 values of the parental cell line from the viabilities, calculating the logarithmic values of the ratios, and calculating the correlation coefficients among the known genes based on these logarithmic values; the database constructed by such a method; and a method of analyzing gene function of unknown genes is elucidated from the correlation coefficients of the function-unknown gene to each of the known genes in the database. |
