TRANSITION STATE STRUCTURE OF 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASES

摘要

Provided are methods of designing a putative inhibitor of a 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. The methods comprise designing a chemically stable compound that resembles the charge and geometry of the 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase transition state. Also provided are methods of inhibiting 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases using the inhibitors found by the above methods.