2-АМИДО-4-АРИЛОКСИ-1-КАРБОНИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ СЕРИНПРОТЕАЗ, В ЧАСТНОСТИ, ПРОТЕАЗЫ NS3-NS4A HCV

摘要

The present invention relates to compounds of formula I-A and I-B
that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.