| 摘要 |
The present invention relates to a method for treating patients having Huntington's disease by a drug increasing the phosphorylation of huntingtin at position S421, thereby decreasing the polyQ-huntingtin-induced toxicity.
Useful compounds are selected from the group consisting of cyclosporin A, FK506, FK520, L685, 818, FK523, 15-0-DeMe- FK-520, Lie120, fenvalerate, resmethrin, cypermethrin, deltamethrin. A method for selecting, identifying or screening a compound useful for treating a subject having Huntington's disease is also disclosed. |
