发明名称 |
IMPROVED ADENOVIRAL VECTORS AND USES THEREOF |
摘要 |
<p>The present invention relates to recombinant adenoviral vectors based on adenoviruses that encounter pre-existing immunity in a minority of the human population and which harbor a chimeric capsid. The chimeric capsid comprises fiber proteins that have at least the knob domain of a human adenovirus that binds to the Coxsackievirus and Adenovirus Receptor (CAR) and a hexon protein from an adenovirus serotype that encounters pre-existing immunity in a low percentage of the human population.</p> |
申请公布号 |
IL182330(D0) |
申请公布日期 |
2007.07.24 |
申请号 |
IL20070182330 |
申请日期 |
2007.03.29 |
申请人 |
CRUCELL HOLLAND B.V.;HAVENGA, MENZO, JANS, EMCO;BETH ISRAEL DEACONESS MEDICAL CENTER INC;BAROUCH, DAN H. |
发明人 |
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分类号 |
C12N |
主分类号 |
C12N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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