| 摘要 |
This invention is directed, inter alia to: 1)improving a lipid profile; 2) methods of reducing circulating lipid levels; 3) methods of increasing high density lipoprotein (HDL) levels; 4) methods of altering ratios of low density lipoprotein to high desnsity lipoprotein levels in a subject; 5) methods of treating atherosclerosis and its associated diseases; and 5) methods of treating ischemia in a male subject with prostate cancer having undergone androgen deprivation therapy; by administering to the subject a SERM compound of formula (I) and/or its N-oxide, ester, isomer, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.
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