| 摘要 |
<p>Method for obtaining (E)-N-(6,6-dimethylhept-2-en-4-ynyl)-N- methyl-1-naphthalenemethanamine, i. e., terbinafine, from a mixture of geometric isomers consists in that terbinafine is precipitated in the form of hydrochloride salt from the C1-5 alcohol solution by addition of an aliphatic C5-7 saturated hydrocarbon or a mixture of C5-7 saturated hydrocarbons in the amount of 0.25 to 3 times of the alcohol volume and under the temperature from -10 °C to boiling point temperature of the employed solvent mixture, wherein (Z)-isomer along with impurities remain in the mother liquor.</p> |
