发明名称 |
NOVEL BLOCK COPOLYMER, MICELLE PREPARATION, AND ANTICANCER AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT |
摘要 |
A medicinal preparation is desired which has no harmful side effects such as hypersensitive reaction, heightens the water solubility of a sparingly water-soluble anticancer agent, maintains a high drug concentration in the blood, accumulates a drug in a tumor tissue at a high concentration, heightens the pharmacological effect of the sparingly water-soluble anticancer agent, and diminishes the side effects of the anticancer agent. Provided are: a novel block copolymer which can be a drug carrier having no harmful side effects such as hypersensitive reaction; a micelle preparation in which micelles are formed and which contains a sparingly water-soluble anticancer agent, especially paclitaxel, incorporated in the micelles in an amount necessary for a disease treatment without bonding it to the block copolymer and which can heighten the solubility of the drug in water; and an anticancer agent which comprises the micelle preparation as a medical ingredient, maintains a high concentration in the blood, has more potent drug activity, and is reduced in toxicity. |
申请公布号 |
EP1792927(A1) |
申请公布日期 |
2007.06.06 |
申请号 |
EP20050783310 |
申请日期 |
2005.09.16 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
SHIMIZU, KAZUHISA;ISHIKAWA, KEIZOU;NAKANISHI, TAKESHI |
分类号 |
C08G69/40;A61K9/107;A61K31/337;A61K45/00;A61K47/34 |
主分类号 |
C08G69/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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