| 发明名称 |
Method for inhibiting gene expression promoted by AP1 protein with RAR beta selective retinoids and method for treatment of diseases and conditions with such retinoids |
| 摘要 |
Retinoid compounds which repress expression of the gene promoted by AP1 protein but which do not significantly activate expression of the genes having RA-responsive elements in their promoter region through RAR alpha and RAR GAMMA receptor subtypes, are used, with reduced side effects, for treating diseases and conditions which are responsive to therapy with retinoids.
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| 申请公布号 |
US6025388(A) |
申请公布日期 |
2000.02.15 |
| 申请号 |
US19950428957 |
申请日期 |
1995.04.26 |
| 申请人 |
ALLERGAN SALES, INC. |
发明人 |
NAGPAL, SUNIL;SONG, TAE K.;VULIGONDA, VIDYASAGAR;ATHANIKAR, JYOTI;CHANDRARATNA, ROSHANTHA A. |
| 分类号 |
C07D309/12;A61K31/35;A61K31/351;A61K31/443;A61K31/455;A61P9/10;A61P17/00;A61P35/02;A61P43/00;C07D405/12;(IPC1-7):A01N43/16;A01N43/40 |
主分类号 |
C07D309/12 |
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