Piperidine derivative having nmda receptor antagonistic activity

摘要

A piperidine derivative of the formula (I) is found to bind specifically with the NR1/NR2B receptor and usable as an analgesic (pain treatment drug). wherein X is OH or lower alkylsulfonyloxy; Ar is optionally substituted aryl or optionally substituted heteroaryl; n is an integer of 1 to 4; m is an integer of 0 to 1; R¹ is hydrogen; R² is OH or R¹ and R² taken together may form a single bond; excluding that 1) n is 2; m is 0; R¹ and R² taken together may form a single bond; and Ar is optionally substituted phenyl and 2) n is 3; m is 0; R¹ and R² taken together may form a single bond; and Ar is phenyl.