发明名称 |
ORAL RIBAVIRIN PHARMACEUTICAL COMPOSITIONS |
摘要 |
The invention relates to oral pharmaceutical compositions for the prevention and/or the treatment of viral diseases. This invention also addresses methods of prevention and/or treatment of these viral diseases, using these oral compositions. One of the main problems considered in the present invention, is to enhance the efficiency of anti-viral treatments, especially against Hepatitis C by means of ribavirin, for example in combination with interferon. The oral ribavirin antiviral composition according to the invention increases the bio-absorption time of ribavirin, and thus improves the treatment of the patients. Said composition comprises at least one modified release form of ribavirin which bio-absorption time BAT is greater than the bio-absorption time BAT* of a reference* immediate release form of ribavirin administered at the same dose; BAT being preferably comprised between 2 and 15 hours and more preferably between 4 and 12 hours. Said composition is a reservoir type form or a matricial type form. Said composition is a gastric retentive system or a multiparticulate form. |
申请公布号 |
WO2006131566(A3) |
申请公布日期 |
2007.04.12 |
申请号 |
WO2006EP63070 |
申请日期 |
2006.06.09 |
申请人 |
FLAMEL TECHNOLOGIES;SOULA, GERARD;MEYRUEIX, REMI;GUIMBERTEAU, FLORENCE;CASTAN, CATHERINE |
发明人 |
SOULA, GERARD;MEYRUEIX, REMI;GUIMBERTEAU, FLORENCE;CASTAN, CATHERINE |
分类号 |
A61K9/52;A61K9/26;A61K31/7056 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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