CAMPTOTHECIN ANALOGUES, PROCESS FOR THEIR PREPARATION, USE AND FORMULATIONS CONTAINING THEM

摘要

The present invention relates to novel camptothecin derivatives of general formula (I) in which R<SUB>1</SUB> is a straight or branched polyamino residue, optionally functionalized by acylation or alkylation of the amino residues with more than 2 nitrogen atoms; R<SUB>2</SUB> is H, -OR<SUB>3</SUB>; R<SUB>3</SUB> is H or a straight or branched C<SUB>1</SUB>-C<SUB>24</SUB> saturated or unsaturated acyl residue; R<SUB>4</SUB> is H, straight or branched C<SUB>1</SUB>-C<SUB>4</SUB> alkyl, hydroxyalkyl, aminoalkyl or cyano; R<SUB>5</SUB> and R<SUB>6</SUB> can be H, OH or OCH<SUB>3</SUB>. The compounds of the present invention can be conveniently administered for the therapy of tumors, in the form of suitable pharmaceutical formulations.