AMIDE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3-BETA INHIBITORS

摘要

This invention concerns a compound of formula (I'),a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; Ris hydrogen; aryl; formyl; Calkylcarbonyl; optionally substituted Calkyl; Calkyloxycarbonyl; optionally substituted Calkyloxy Calkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; Ris hydrogen, Calkyl, Calkenyl, Calkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; Ris hydrogen; hydroxy; halo; optionally substituted Calkyl or Calkenyl or Calkynyl; Calkyloxy; Calkylthio; Calkyloxycarbonyl; Calkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(Calkyl)amino; polyhaloCalkyl; polyhalo Calkyloxy; polyhaloCalkylthio; R; R-Calkyl; R-O-; R-S-; R-C(=O)-; R-S(=O)-; R-S (=O)-; R-S (=O)-NH-; R-S (=O)-NH-; R-C(=O)-; -NHC(=O) H;--C(=O) NHNH; R-C (=O)-NH; R-C(=O)-NH-; -C (=NH) R; -C (=NH)R; Ror Reach independently represent hydrogen, R, -Y-NR-Y-NRR, -Y-NR-Y-R, -Y-NR'R; provided that -X-Rand/or Ris other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.