Process for preparation of cyclosporin A analogues having a terminal diene group

摘要

A new process for the preparation of a cyclosporin A analog of formula I comprising: a) allylating a protected cyclosporin A aldehyde with a allylmetal reagent and b) converting the compound obtained in step a) to the cyclosporin A analog of formula I has been identified. Intermediates for this process and processes for the preparation of such intermediates are also discussed.