| 摘要 |
The invention relates to oral pharmaceutical formulations for the prevention and/or the treatment of chronic cyclooxygenase (COX)-2 mediated diseases or conditions, ie the inflammatory diseases or conditions, while reducing the risk of thrombotic cardiovascular and. This invention also addresses methods of prevention and/or treatment of these diseases, using these oral pharmaceutical formulations. The oral pharmaceutical formulation comprises a combination of at least one active principle for treating a chronic cyclooxygenase(COX)-2 mediated disease or condition and of microcapsules for the controlled release of acetylsalicylic acid (ASA), in the gastrointestinal environment.
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