发明名称 |
PROCESS FOR PREPARING VARIANT OF ERYSIPELOTHRIX RHUSIOPATHIAE SURFACE PROTECTIVE ANTIGEN IN E. COLI |
摘要 |
A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (”SpaA) in which a portion of SpaA protein is deleted for protection from Erysipelothrix rhusiopathiae infection and a process for preparing the same are provided. Introduction of amino acid substitution at a specific site in the amino acid sequence of SpaA or ”SpaA protein provides a variant of SpaA or ”SpaA protein which is immunogenic and is expressed in E. coli as inclusion bodies. The variant of SpaA or ”SpaA protein of the present invention may easily be recovered and purified since it is expressed in E. coli as inclusion bodies.
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申请公布号 |
EP1724342(A1) |
申请公布日期 |
2006.11.22 |
申请号 |
EP20050709866 |
申请日期 |
2005.02.08 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
USHIJIMA, TOSHIHIRO;SAKAGUCHI, MASASHI;TOKUNAGA, EIJI |
分类号 |
A61K39/00;C12N15/09;A61K38/00;A61K38/16;A61P31/00;C07K14/195;C12P21/02 |
主分类号 |
A61K39/00 |
代理机构 |
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