VASOCONSTRICTIVE SUBSTITUTED 2,3-DIHYDRO-1,4-DIOXINOPYRIDINES

摘要

The present invention is concerned with compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein =a1-a2=a3-a4= is a bivalent radical of formula (a): =N-CH=CH-CH=, (b): =CH-NCH-CH=, (c): =CH-CH=N-CH=, (d): =CH-CH=CH-N=, wherein one or two hydrogen atoms can be substituted by halo hydroxy, C1-6 alkyl or C1-6 alkyloxy; R1 is hydrogen or C1-6 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is hydrogen or C1-6 alkyl; Alk1 is C1-5 alkanediyl; Alk2 is C2-15 alkanediyl; Q is a five- or six-membered heterocyclic ring containing at lea st one nitrogen atom or a radical of formula -C(NR5R6)=C-R4 wherein R4 is hydrogen, cyano aminocarbonyl or C1-6 alkyl; R5 is hydrogen C1 -6 alkyl, C3-6 alkenyl or C3-6 alkynyl; R6 is hydrogen or C1-6 alkyl; or R5 and R6 taken together may form a bivalent radical of formula - (CH2)4- or -(CH2)5-. Pharmaceutical compositions, preparations and use as a medicine are described.