WATER-SOLUBLE COENZYME Q10 IN INCLUSION COMPLEX WITH BETA-CYCLODEXTRIN, PROCESS OF PREPARING, AND USE THEREOF

摘要

This invention relates to an inclusion complex of coenzyme Q10 with ß­cyclodextrin, prepared in an unobvious manner, wherein ß-cyclodextrin is dissolved in water at a temperature higher than room temperature, preferably between 55 °C and the boiling temperature, then coenzyme Q10 is added either in solid form or dissolved in an appropriate solvent, preferably in solid form, the stirring is continued at increased temperature, then at room temperature or lower than room temperature. The formation of said complex enhances the water solubility of the coenzyme Q10 significantly, whereby its dissolution characteristics, bioavailabilty, and prophylactic or therapeutical effectiveness are improved as well. Thus the invention solves in a simple and unobvious manner the problem of poor water-solubilty of coenzyme Q10. Hitherto, this rendered difficult the preparation of effective preparations with this enzyme on a non-lipophilic base, as well as its addition to various products, especially alimentary, cosmetic and pharmaceutical products. Accordingly, the invention relates to said inclusion complex, to a process of preparing such a complex, and to the use of the latter for the supplementation of pharmaceutical, cosmetic and alimentary products.