ANTIBODIES SPECIFICALLY REACTING WITH PRIONIC PROTEIN OR ITS FRAGMENT, AND THEIR APPLICATION

摘要

FIELD: medicine, biotechnology. ^ SUBSTANCE: the present innovation deals with elaborating diagnostic reagents for testing prionic protein in mammalian cerebral tissue due to IEA technique and refers to antibodies specifically reacting with prionic protein PrP or its fragment. The innovation includes polyclonal antibodies obtained to synthetic peptides including amino acid sequences of bovine prionic protein 143-168, 101-134 and 211-241, their conjugates with horseradish peroxidase and diagnostic reagents obtained upon their basis that enable to detect prionic protein in mammalian cerebral tissues. ^ EFFECT: higher specificity of detection. ^ 15 cl, 8 ex, 8 tbl