发明名称 |
Novel anti-arrhythmic and heart failure drugs thattarget the leak in the ryanodine receptor (ryr2) and uses thereof |
摘要 |
The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac death in a subject. Additionally, the present invention provides use of JTV-519 in a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject who has, or is a candidate for, atrial fibrillation. Also provided are uses of 1,4-benzothiazepine derivatives in methods for treating and preventing atrial and ventricular cardiac arrhythmias and heart failure in a subject, and for preventing exercise-induced sudden cardiac death. The present invention also provides methods for identifying agents for use in treating and preventing atrial fibrillation and heart failure, and agents identified by these methods.
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申请公布号 |
WO2005094457(B1) |
申请公布日期 |
2006.06.29 |
申请号 |
WO2005US09495 |
申请日期 |
2005.03.22 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK |
发明人 |
MARKS, ANDREW, R.;LANDRY, DONALD, W.;DENG, SHIXIAN;CHENG, ZHEN, ZHUANG |
分类号 |
A61K31/553;A61K31/554 |
主分类号 |
A61K31/553 |
代理机构 |
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主权项 |
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地址 |
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