| 摘要 |
The present invention provides an efavirenz tablet formulation which, when administered as a single dose to a subject, provides a mean maximum plasma concentration (Cmax) of about 4 muM to about 14 muM, a mean time of maximum plasma concentration (Tmax) of about 2 hours to about 5 hours, and a mean area under the plasma concentration versus time curve from time zero to time infinity (AUC) of about 190 muM<img id="custom-character-00001" he="2.79mm" wi="1.02mm" file="US20060057196A1-20060316-P00900.TIF" alt="custom character" img-content="character" img-format="tif"/>hour to about 470 muM<img id="custom-character-00002" he="2.79mm" wi="1.02mm" file="US20060057196A1-20060316-P00900.TIF" alt="custom character" img-content="character" img-format="tif"/>hour.
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