发明名称 |
TRANSPOSON-INSULATOR ELEMENT DELIVERY SYSTEMS |
摘要 |
Certain embodiments are directed to using an insulator element in a transposon having at least one transcriptional unit and at least one insulator element. The transcriptional unit(s) may be flanked by at least one insulator element on each side. The transcriptional unit may include an exogenous nucleic acid for introduction into a cell, e.g., DNA encoding a marker molecule. The insulator element may include a binding site for a CTCF protein. And, for example, a transcriptional unit may be disposed between a first insulator element and a second insulator element, and the first insulator element and the second insulator element may be disposed between inverted repeats of a transposon. The exogenous nucleic acid may be, e.g., DNA encoding an antisense RNA or siRNA. |
申请公布号 |
WO2004065581(A3) |
申请公布日期 |
2006.01.19 |
申请号 |
WO2004US00977 |
申请日期 |
2004.01.15 |
申请人 |
DISCOVERY GENOMICS, INC. |
发明人 |
HACKETT, PERRY, B.;MCIVOR, SCOTT;CLARK, KARL, J.;CALDOVIC, LUBA |
分类号 |
A61K48/00;C12N15/74;C12N15/85 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|