发明名称 |
INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE |
摘要 |
<p>The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.</p> |
申请公布号 |
EP1613620(A1) |
申请公布日期 |
2006.01.11 |
申请号 |
EP20040759361 |
申请日期 |
2004.04.09 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
COTTRELL, KEVIN, M.;MAXWELL, JOHN;PERNI, ROBERT, B.;PITLIK, JANOS |
分类号 |
A61K31/40;A61K38/04;C07D403/12;C07K5/04;C07K5/10;(IPC1-7):C07D403/12 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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