发明名称 |
IMMUNOSTIMULATORY NUCLEIC ACIDS FOR INDUCING IL-10 RESPONSES |
摘要 |
The invention relates to methods and products for inducing IL-10 expression using immunostimulatory nucleic acids. In particular, the invention relates to methods and products for inducing IL-10 expression without inducing high levels of IFN-alpha expression. IL-10-inducing immunostimulatory nucleic acids preferably include a TC dinucleotide at the 5' end and a CG dinucleotide towards the 3' end, but not near the 5' end. The invention is useful for treating and preventing disorders associated with a Thl or Th2 immune response or for promoting a T regulatory cell environment suitable for suppressing inappropriate immune responses (e.g., for controlling or suppressing excessive immune responses). |
申请公布号 |
WO2005111057(A2) |
申请公布日期 |
2005.11.24 |
申请号 |
WO2005US11827 |
申请日期 |
2005.04.04 |
申请人 |
COLEY PHARMACEUTICAL GROUP, INC.;COLEY PHARMACEUTICAL GMBH;KRIEG, ARTHUR, M.;VOLLMER, JOERG |
发明人 |
KRIEG, ARTHUR, M.;VOLLMER, JOERG |
分类号 |
C07H21/00;C12N15/117;(IPC1-7):C07H21/00 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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地址 |
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