| 发明名称 |
QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS |
| 摘要 |
The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R1, X, R3, x, and ring A are as defined in the present application.
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| 申请公布号 |
KR20050108379(A) |
申请公布日期 |
2005.11.16 |
| 申请号 |
KR20057016287 |
申请日期 |
2005.09.01 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
GONZALES JESUS E. III;WILSON DEAN MITCHELL;TERMIN ANDREAS PETER;GROOTENHUIS PETER DIEDERIK JAN;ZHANG YULIAN;PETZOLDT BENJAMIN JOHN;FANNING LEV TYLER DEWEY;NEUBERT TIMOTHY DONALD;TUNG ROGER D.;MARTINBOROUGH ESTHER;ZIMMERMANN NICOLE |
| 分类号 |
A61K31/517;A61K31/5377;A61K31/541;C07D;C07D239/91;C07D239/94;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/12;C07D405/14;C07D409/04;C07D409/12;C07D409/14;C07D413/02;C07D413/12;C07D417/02;C07D417/12;C07D417/14;C07D471/04;C07D487/04;C07D498/04;(IPC1-7):C07D239/94 |
主分类号 |
A61K31/517 |
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