| 摘要 |
This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula (I) wherein R1 is selected from H or COR4; R4 is C1-C6 alkyl or C1-C6 alkoxy; R3 is C1-C6 alkyl; Z1 is - CH2- or Formula (II) wherein O-COR4 is in the alpha configuration; Z2 is -CH-; or Z1 and Z2 may be taken together to form a carbon-carbon double bond; Q is Formula (III). These intermediates are useful in the preparation of 7-carboxy substituted steroid compounds, and particularly, the invention is directed to novel and advantageous methods for the preparation of 9,11-alpha-epoxy-17-alpha-hydroxy-3-oxopregn-4- ene-alpha-7-21-dicarboxylic acid, gamma-lactone, methyl ester (eplerenone; epoxymexrenone).
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