发明名称 |
Design and synthesis of renal dipeptidase inhibitors |
摘要 |
Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
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申请公布号 |
US6927212(B2) |
申请公布日期 |
2005.08.09 |
申请号 |
US20030627991 |
申请日期 |
2003.07.28 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
KHAN SAEED R.;VOGELSTEIN BERT;KINZLER KENNETH W.;GURULINGAPPA HALLUR;BUCKHAULTS PHILLIP |
分类号 |
C07B59/00;C07F9/30;(IPC1-7):A61K31/66;C07F9/02 |
主分类号 |
C07B59/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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