AN IMPROVED PROCESS FOR THE PREPARATION OF 7-CHLORO-4-(5-N-EHTYL-N-2-HYDROXYETHYLAMINE)-2-PENTYL] AMINOQUINOLINE AND ITS INTERMEDIATES

摘要

Disclosed herein is an improved process for the preparation of 7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline comprising of condensation reaction of 4,7 - dichloro quinoline with 5-(n-ethyl-N-2-hydroxyethyl amino)-2-pentylamine and its intermediates which comprises the reaction of protected 1-chloro-4-pentanone with substituted amine followed by deprotection of ketogroup and reductive amination yielding 5-(N-ethyl-N-2-hydroxyethyl amino)-2-pentylamine or 5 - (N,N-diethylamino) - 2 - pentylamine.