| 摘要 |
The invention relates to a method for at least in part inhibiting differentiation of stem cells in a population of mammalian cells comprising upregulating a Wnt signaling pathway to a differentiation inhibiting level i n said population of cells. The invention increases at the same time the numbe r of stem cells in a population of mammalian cells compared to a reference population, and induces at least in part apoptosis in mesenchymal cell in a population of mammalian cells The invention also discloses a method for selective differentiation of a stem cell, comprising controlling the level o f Wnt pathway activation. The invention is used for the proliferation and subsequent differentiation of embryonic stem cells and lung stem cells, and for ex vivo lung explant cultivation. |
