| 摘要 |
A METHOD OF MAKING MICROBALLS IS DISCLOSED. AN ACTIVE INGREDIENT, A BIOCOMPATIBLE POLYMER AND A SUPPORTING PHASE, SUCH AS SILICONE OIL, ARE STIRRED AT A TEMPERATURE ABOVE THE TG OF THE POLYMER AND BELOW THE TEMEPRATURE AT WHICH ANY OF THE IGREDIENTS VAPORIZES OR DEGRADES. STIRRING IS CONTINUED UNTIL MICROBALLS OF THE DESIRED DIAMETER ARE FORMED, WHEREAFTER THE MIXTURE IS COOLED AND THE MICROBALLS ARE SEPARATED FROM THE SUPPORTING PHASE. THE MICROBALLS ARE SUBSTANTIALLY SPHERICAL. SUBSTANTIALLY SMOOTH ON THEIR EXTERNAL SURFACE AND HAVE SUBSTANTIALLY NO ACTIVE INGREDIENT ON THEIR EXTERNAL SURFACE.
|
