IL-18 BINDING PROTEINS

摘要

The present invention encompasses IL-18 binding proteins, particularly
antibodies that bind
human interleukin-18 (hIL-18). Specifically, the invention relates to
antibodies that are
entirely human antibodies. Preferred antibodies have high affinity for hIL-18
and/or that
neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention
can be a full-length
antibody or an antigen-binding portion thereof. Method of making and method of

using the antibodies of the invention are also provided. The antibodies, or
antibody
portions, of the invention are useful for detecting hIL-18 and for inhibiting
hIL-18 activity,
e.g., in a human subject suffering from a disorder in which hIL-18 activity is
detrimental.