发明名称 |
USE OF UREASE FOR INHIBITING CANCER CELL GROWTH |
摘要 |
A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject. |
申请公布号 |
EP1530482(A1) |
申请公布日期 |
2005.05.18 |
申请号 |
EP20030764850 |
申请日期 |
2003.07.16 |
申请人 |
HELIX BIOPHARMA CORP. |
发明人 |
CHAO, HEMAN;WONG, WAH;SEGAL, DONALD;MCELROY, JERRY;DOCHERTY, JOHN;DICKSTEIN, JODI |
分类号 |
A61K38/50;A61K47/48;A61K48/00;A61P35/00;B82Y5/00;(IPC1-7):A61K38/50 |
主分类号 |
A61K38/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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