发明名称 |
METABOLIC CONTROLLED FERMENTATION PROCESS FOR CARBAMOYL TOBRAMYCIN PRODUCTION |
摘要 |
A metabolic controlled fermentation process has been developed for the production of carbamoyl tobramycin by the application of different Streptomyces tenebrarius strains in submerged cultures at a temperature within about 37-41° C. on a medium containing assimilable carbon and nitrogen sources, mineral salts and controlling the assimilable carbon and nitrogen sources by feeding in an optimal range. As a result of this invention a high yield production of carbamoyl tobramycin with high purity could be achieved. |
申请公布号 |
PL368609(A1) |
申请公布日期 |
2005.04.04 |
申请号 |
PL20020368609 |
申请日期 |
2002.01.09 |
申请人 |
BIOGAL GYOGYSZERGYAR RT. |
发明人 |
BAKONDI-KOVACS ISTVAN;NOVOTNY ILONA CSUTOROS;ERDEI JANOS;BALOGH GABOR;SERESS PETER |
分类号 |
C12P19/48;A61K31/70;A61K31/7028;A61P31/04;C07H15/04;C12P19/26;C12R1/465 |
主分类号 |
C12P19/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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