FKI-1366 SUBSTANCES AND PROCESS FOR PRODUCING THE SAME

摘要

A microorganism belonging to Beauveria sp. and being capable of producing FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C (Beauveria sp. FKI-1366, FERM BP-08459) is cultured in a medium and thus the FKI-1366 substance A and/or the FKI-1366 substance B and/or the FKI-1366 substance C are accumulated in the culture medium. Then the FKI-1366 substance A and/or the FKI-1366 substance B and/or the FKI-1366 substance C are collected from the culture medium. The thus obtained FKI-1366 substance A, FKI-1366 substance B and FKI-1366 substance C or compositions thereof have an effect of potentiating the activity of azole antifungal agents. Thus, they act against various fungal infections such as deep-seated fungal infection at a low concentration and within a short time. Therefore, they are useful in lowering the appearance frequency of tolerant strains and overcoming tolerance, thereby being expected as useful drugs.