MICROCAPSULES WITH MODIFIED RELEASE OF ACTIVE PRINCIPLES WITH LOW SOLUBILITY FOR ORAL DELIVERY

摘要

The invention concerns microcapsules for reliably modified release and adapted to industrial reproduction of an active principle hardly water- soluble, other than anti-hyperglycemia agents Each of said microcapsules comprises a core of hardly soluble active principle and a coating film applied on the core. Their mean diameter is less than 1000 microns. The coating film contains a film-forming polymer (P1) insoluble in gastrointestinal tract fluids, a water-soluble polymer (P2), a plasticizer (PL), and optionally a lubricating surfactant (TA). Said coating film represents at least 4 % p/p of dry matter of their total weight, and its components P1, P2, PL satisfy the following characteristics: dry weight mass fraction of P1 relative to the total coating weight ranging between 40 and 90 %; dry matter weight fraction of PL/P1+P2 ranging between 15 and 60 %; dry matter weight fraction of PL/P1+ PL ranging between 1 and 30 %. The invention also concerns the uses of said microcapsules in galenic formulation.