METHOD AND COMPOSITION OF ADMINISTERING RADIOPROTECTANTS

摘要

The present invention relates to methods and compositions for the prevention and treatment of radiation-associated tissue damage. Specifically, the present invention relates to methods for simultaneously delivery of amifostine and Vitamine E at the target sites of 0 mammal to enhance the therapeutical effect and to 35duce the toxicity attributabe to amifostine. The present invention 0lso relates to @h03maceutical compositions for the prevention and treatment of 0 radiation-associated tissue damage. The present pharmaceutical compositions are particularly useful for the protection to against radiation-induced suppression of the hematopoietic system as well as to enhance bone marrow stem cells activity. The present invention further relates to 0 pharmaceutical kit for the prevention and treatment of 0 radiation-associated tissue damage.