Enhancement of bone growth and inhibition of bone resorption

摘要

This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula: <CHEM> A is H, R, or (CH2)n <CHEM> each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, halogen, R, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR', ROH, ROR', RSH, RSR', NHR, NRR', RNHR', or RNR'R"; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; wherein each of R, R', and R", independently is C1 SIMILAR C6 alkyl; and n is 1, 2, or 3. These compounds are useful in the treatment of osteoporosis, bone fracture, short stature, failed arthrodesis, dyschondroplasia, achondroplasia, or congenital pseudoarthrosis.