TRANSGENIC ANIMAL HAVING AN AMYLOID PRECURSOR PROTEIN WITH AMODIFIED BETA SECRETASE CLEAVAGE SITE

摘要

The present invention provides transgenic animals having an amyloid precurso r protein wherein the amino acids flanking the beta secretase cleavage si te are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention further provides methods of screening candidate compounds to determine whether the compounds can alter the rate of cleavage of amyloid precursor protein by beta secretase.