The present invention concerns methods and systems for analysis of drug resistance in HIV-1. More specifically, the invention provides methods for predicting drug resistance by correlating genotypic information with phenotypic profiles. The methods allow the identification of primary and secondary resistance-associated mutations for new and existing drugs and for calculating the contribution of mutations and combinations of mutations to resistance and hyper-susceptibility. The invention allows the design, optimization and assessment of the efficiency of a therapeutic regimen based upon the genotype of the disease affecting a patient.
申请公布号
WO2004111907(A2)
申请公布日期
2004.12.23
申请号
WO2004EP51084
申请日期
2004.06.10
申请人
VIRCO BVBA;VAN MARCK, HERWIG, GASTON, EMIEL;VAN DEN BULCKE, TIM, GERRIT;VERMEIREN, HANS, VICTOR
发明人
VAN MARCK, HERWIG, GASTON, EMIEL;VAN DEN BULCKE, TIM, GERRIT;VERMEIREN, HANS, VICTOR